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Interactive Infusion Administration Video | HCP
  1. Dosing and Administration
  2. Infusion video

THE SIMPONI ARIA® INFUSION ADMINISTRATION VIDEO

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INFUSION SUPPLY LIST
 
 
Before each infusion, make sure you have all of the IV access supplies you will need, which may include:
(1) Primary infusion set with Y site positioned close to patient (use only an infusion set with an inline, sterile, nonpyrogenic, low protein-binding filter [pore size 0.22 micrometer or less])*
(1) 100-mL IV bag of 0.9% or 0.45% Sodium Chloride Injection, USP
(1) Safety IV catheter: 22- or 24-gauge x 1" maximum length
(1) Antiseptic swab
Gauze
Medical tape
As needed: tourniquet (nonlatex), gloves
*Infusion sets should meet the Needlestick Safety and Prevention Act of 2001 requiring needle safety systems.
You may order these items through your wholesaler or distributor.
Please note that vials of SIMPONI ARIA® (golimumab) must be purchased separately.
Please read full Prescribing Information, including Boxed Warnings, Important Administration Instructions, and Medication Guide for SIMPONI ARIA®. Provide the Medication Guide to your patients and encourage discussion.
  • Vital signs
  • Weight
  • Any changes in medical history
  • Any changes in medication history
  • Allergies, especially to medications
IMPORTANT: This assessment must be performed before every infusion.
Please read full Prescribing Information, including Boxed Warnings, Important Administration Instructions, and Medication Guide for SIMPONI ARIA® (golimumab). Provide the Medication Guide to your patients and encourage discussion.
  • Serious infections
  • Malignancies
  • Hepatitis B reactivation
  • Heart failure
  • Demyelinating disorders
  • Autoimmunity
  • Use with other drugs
  • Hematologic cytopenias
  • Vaccinations/therapeutic infectious agents
  • Hypersensitivity reactions
  • Adverse reactions
Please read full Prescribing Information, including Boxed Warnings, Important Administration Instructions, and Medication Guide for SIMPONI ARIA® (golimumab). Provide the Medication Guide to your patients and encourage discussion.
ONLINE DOSING CALCULATOR

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Please read full Prescribing Information, including Boxed Warnings, Important Administration Instructions, and Medication Guide for SIMPONI ARIA® (golimumab). Provide the Medication Guide to your patients and encourage discussion.

 

 

STEP 1: Calculate the dosage and number of vials needed based on the recommended dosage of 2 mg/kg and the patient’s weight. Each 4-mL vial of SIMPONI ARIA® (golimumab) contains 50 mg of golimumab.
STEP 2: Check the solution in each vial. The liquid should be colorless to light yellow. The solution may develop a few fine translucent particles, as golimumab is a protein.
Do not use if opaque particles, discoloration, or other foreign particles are present.
STEP 3: Prepare the solution for infusion:
  • Prior to administration, dilute the total volume of the SIMPONI ARIA® solution with 0.9% Sodium Chloride Injection, USP to a final volume of 100 mL
    —For example, this can be accomplished by withdrawing a volume of the 0.9% Sodium Chloride Injection, USP from the 100-mL infusion bag or bottle equal to the total volume of SIMPONI ARIA®
  • Slowly add the total volume of SIMPONI ARIA® solution to the 100-mL infusion bag or bottle
  • Gently mix
  • Discard any unused solution remaining in the vials
STEP 4: Visually inspect the diluted SIMPONI ARIA® solution. If particulate matter or discoloration exists, DO NOT USE.
STEP 5: Use only an infusion set with an inline, sterile, nonpyrogenic, low protein-binding filter (pore size 0.22 micrometer or less).
IMPORTANT: Do not infuse SIMPONI ARIA® concomitantly in the same intravenous line with other agents.
STEP 6: Infuse the diluted solution over 30 minutes.
IMPORTANT: Once diluted, the infusion solution can be stored for 4 hours at room temperature.
Please read full Prescribing Information, including Boxed Warnings, Important Administration Instructions, and Medication Guide for SIMPONI ARIA®. Provide the Medication Guide to your patients and encourage discussion.
 
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DOSING TOOLS
 
ADMINISTRATION
INSTRUCTIONS

This video discusses use in moderately to severely active RA only. While dosing with methotrexate varies by indication, SIMPONI ARIA® administration instructions apply to all indications.

  • 2 mg/kg intravenous infusion over 30 minutes at Weeks 0 and 4, then every 8 weeks
  • Dilution of supplied SIMPONI ARIA® solution with 0.9% Sodium Chloride Injection, USP is required prior to administration. Alternatively, 0.45% Sodium Chloride injection, USP can also be used

Please see the full Prescribing Information for SIMPONI ARIA® for dosing and administration instructions.

Download the Dosing and Administration Guide for more information about dosing