INFUSION ADMINISTRATION INSTRUCTIONS
SIMPONI ARIA® solution for IV infusion should be diluted by a healthcare professional using aseptic technique as follows:
Check that the solution in each vial is colorless to light yellow. The solution may develop a few fine translucent particles, as golimumab is a protein. Do not use if opaque particles, discoloration, or other foreign particles are present.
SIMPONI ARIA® solution with 0.9% w/v sodium chloride for infusion to a final volume of 100 mL. For example, this can be accomplished by withdrawing a volume of the 0.9% w/v sodium chloride solution from the 100-mL infusion bag or bottle equal to the total volume of SIMPONI ARIA®.Dilute the total volume of the
- Slowly add the total volume of SIMPONI ARIA® solution to the 100-mL infusion bag or bottle
- Gently mix
- Discard any unused solution remaining in the vials
Prior to infusion, visually inspect the diluted SIMPONI ARIA® solution for particulate matter or discoloration. Do not use if these exist.
Use only an infusion set with an in-line, sterile, non-pyrogenic, low protein-binding filter (pore size 0.22 micrometer µm or less).
Do not infuse SIMPONI ARIA® concomitantly in the same IV line with other agents. No physical biochemical compatibility studies have been conducted to evaluate the use of SIMPONI ARIA® with other IV agents in the same IV line.
Infuse the diluted solution over a period of 30 minutes.
Once diluted, the infusion solution can be stored for 4 hours at room temperature.